CME Live: Hemolytic Uremic Syndrome

CME Live: Hemolytic Uremic Syndrome

Dr Siddhartha Sethi

Curofy- India's largest community of verified doctors covered the CME-International Neonatal and Pediatric Nephrology Training Workshop live. This post was first published on the Curofy app. 

Etiology
Infection: Shiga and verocytotoxin
Steptococcus Pneumoniae disorders: 

a) genetic disorders of complement regulation
b) Acquired disorders of complement regulation

VonWillebrand proteinase:

a) Genetic disorder
b) Acquired
HIV
Malignancy
Lupus

Complement studies should be a part of every HUS evaluation
Diarrhea+ HUS in young, severe, recurrent, family history
Early: plasma infusions, plasma exchange
Recurrence post renal transplant
Immunosuppression 
Eculizumab

Renal transplant in HUS
High rate of recurrence
Factor H & I mutation
Patients ideally not living related to non-Stx-HUS

Eculizumab: most expensive drug trial