This week's Transplantation journal has an excellent study on CMV prophylaxis in pediatric renal transplantation.
It shows:
Conclusions: Antiviral chemoprophylaxis with VGCV or GCV in recipients with a high or moderate CMV risk is associated with a better preservation of transplant function. Hence, the prevention of CMV replication in this patient population has the potential to improve transplant outcome.
It shows:
- chemoprophylaxis was associated with a better preservation of transplant function at 3 years posttransplant
- CMV replication was associated with a more pronounced decline of graft function
Conclusions: Antiviral chemoprophylaxis with VGCV or GCV in recipients with a high or moderate CMV risk is associated with a better preservation of transplant function. Hence, the prevention of CMV replication in this patient population has the potential to improve transplant outcome.
