An interesting abstract from Turkey published in Journal of Urology 2009 on looking at the peak detrusor pressures and the risk of upper tract damage in these children. It challenges the McGuire study on leak point pressures published in 1981.
Detrusor leak point pressure evolved from the research of McGuire in the early 1980s (McGuire, Woodside, Borden, & Weiss, 1981). McGuire, Woodside, and Borden (1983) studied a population of myelodysplastic children and noted a correlation between the DLPP and the likelihood of upper-tract deterioration. Of the 42 patients studied, 22 had DLPP > 40 cm H2O. In that group, vesicoureteral reflux occurred in 68% and ureteral dilatation in 81%. In long-term followup, patients with the DLPP > 40 cm H2O developed upper-tract deterioration at a rate of 100% (McGuire et al., 1983).
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Detrusor leak point pressure evolved from the research of McGuire in the early 1980s (McGuire, Woodside, Borden, & Weiss, 1981). McGuire, Woodside, and Borden (1983) studied a population of myelodysplastic children and noted a correlation between the DLPP and the likelihood of upper-tract deterioration. Of the 42 patients studied, 22 had DLPP > 40 cm H2O. In that group, vesicoureteral reflux occurred in 68% and ureteral dilatation in 81%. In long-term followup, patients with the DLPP > 40 cm H2O developed upper-tract deterioration at a rate of 100% (McGuire et al., 1983).
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