Maternal NSAIDs and Renal Tubular Dysgenesis in neonates

Just saw a neonate whose mother took Nimesulide whole of her pregnancy for pain abdomen, and now the child is in renal failure. It is a difficult task counselling these parents with a neonate with renal failure.

Renal tubular dysgenesis (RTD) is characterized by absent or poorly developed proximal convoluted tubules.
The glomeruli appear numerous because of the absent proximal tubules in the cortex. Tubules are dilated, and the interstitium is expanded. RTD has been reported to occur as an inherited genetic defect. It has been recognized as a characteristic feature of angiotensin-converting enzyme (ACE) inhibitor foetopathy. It has also been reported sporadically in association with exposure to other drugs, notably the non-selective, non-steroidal, antiinflammatory drugs

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Managing FSGS: New targets

Current Issue of Kidney International has an excellent review on potential targets for treating FSGS in future years. It is a must read for all researchers and scholars!

Controversies and Management of Cystinosis

Current Issue of Kidney International has an excellent paper on Cystinosis- from diagnosis to management, a must read for all pediatricians and pediatric nephrologists.
Nephropathic cystinosis is an autosomal recessive metabolic, lifelong disease characterized by lysosomal cystine accumulation throughout the body that commonly presents in infancy with a renal Fanconi syndrome and, if untreated, leads to end-stage kidney disease (ESKD) in the later childhood years.

CME Live: Session four

Curofy- India's largest community of verified doctors covered the CME-International Neonatal and Pediatric Nephrology Training Workshop live. This post was first published on the Curofy app. 

Neonatal Renal Physiology 

Dr Saroj patnaik

Glomerular function:
Kidney receives 15% of CO 
Low systemic blood pressure
Increased vascular resistance
Renal blood flow more to inner cortex and medulla
GFR is 10-30 ml/min/1.73m2

Limited adaptive features to stress, sepsis, anorexia and exposure to nephrotoxic drugs are challenges in assessing renal function

Autoregulation: 
Range of autoregulation set to lower perfusion pressure
Susceptible to Hypovolemic insult

Tubular function:
Total body water 75% of the weight
Shift of ECF into cells
Physiologic weight loss 10-15%

Low urine concentrating capacity
Dilution mechanism better than conc. capacity
Prone to dehydration
It maybe non oligouric despite poor renal function

Sodium balance: 
Hyponatremia in preterms and rapidly growing LBW babies

Potassium levels of 6-6.5 is considered acceptable in term and preterm neonates

Acid base balance:

Suboptimal acid excretion
Lower serum bicarbonate levels are acceptable in preterm and term neonates
Disease states and drugs can accentuates metabolic acidisis.

Neonatal AKI

Dr Malcolm Coulthard

Why did AK failure become AK injury, it should be AK dysfunction

Deficiency of AK*
Reduced GFR
Reduced urine output


Pre-renal causes:
Hypovolaemia
Non osmotic release of ADH
Renin/endocrine
Renin/paracrine

-Furosemide
does not lead to damage if reverses

Management:
Deal with reversible components
Improve renal perfusion
Sepsis
Surgery
Multiple organ failure

Furosemide if indicated
Obsessional fluid care
Blood results for fine tuning

When to dialyze?
Fluid is the key. If oligouric keep using conservative management until biochemistry is life threatening

CME Live: Session Two

Curofy- India's largest community of verified doctors covered the CME-International Neonatal and Pediatric Nephrology Training Workshop live. This post was first published on the Curofy app. 

Basics of RRT

Speaker: Dr. Pranaw Jha

Dialysis process whereby soluble composition of a solution A is altered by exposing to solution B across a semipermeable membrane
-Need 2 solution- blood & dialysate 
-Semi permeable membrane

Transport mechanisms: 
Diffusion
Convection
Adsorption
Osmosis

Diffusion: 
results in random molecular motion
inversly proportional to solute ssite

Convection:
Ultrafilteration
water driven across semipermeable membrane by hydrostatic/ osmotic force
solvent swept along with it, close to concentrated gradient- solvent drag

Convective methods:
Hemofilterationlarge amount of ultrafilteration coupled with replacement fluid infusion.

Hemodiafilteration: combined HD & HF

Dialysis Modality

Dr. Siddhartha Sethi

Choice of modality
Peritoneal dialysis
intermittent hemodialysis
CRRT

PD is declining in the west, since expertise is increasing. CRRT is used

Modality of choice in India

less expertise in India
not insured in India
expensive

indication of CRRT
prevention of fluid overload

Acute peritoneal dialysis:
indication: Refractory volume overload
refract hyperkalemia
refract metabolic disease
uremia complication
dysnatemias in AKI

Apparatus: 
PD catheter
three way connector
IV sets
PD fluid bags
Drain bag

Catheter: 
Stiff catheter
two cuff tenckhoff's catheter
Cook's catheter
tenckhofs single cuff
soft thermal 

Bicarbonate dialysis
Severe lactic acidosis or hepatic failure
asepsis required
1 hr exchange time

Ultra filtration
Not more than 5-10% weight loss should be targeted

Session length: Stiff catheter are 48-72 hr affair

anuria, hypercatabolism, nutritional support

Additives: 
heparin, potassium, insulin

Disadvantage: 
Slower concentration
lower URA clearance
lower ultra filtration
risks of peritonitis

Automated PD:
warm fluids, keeps track, less infection

Prescribing HD & Mathematics

Dr. Rupesh Raina

Dialysis cannot clear solutes not present in intravascular space.

Diffusion: 

Factors:
Conc. gradient(dC)
surface area(A)
diffusivity(KO)
sum of resistance(dx/KO)
concurrent flow
time
J=KOA x dC/dx

Solutes:
Low molecular weight- uo to 300 daltons
middle molecular weight- 300- 2000 daltons
large molecular weight- 5000- 1200 daltons
serum albumin-69 366 D

Hollow fiber dialyser;
Thousands of hollow capillary sizes fibers fixed in a polyurethane capsules.
blood flows through fibers, dialysate flows around fibers

Clearance: volume of blood cleared of solute per unit time. 
( Refer pic) 

KoA 
Product of the overall mass transfer co efficient for a given solute x dialyser surface area

Ultrafilteration co efficient: ( KUf)

Volume of fluid transferred across the membrane per mmHg of pressure gradient
Low KUf denotes low permeability and low flux
high KUf denotes near complete permeability

High flux of dialyzers: KUf> 14ml/min/mmhg

Urea kinetic modeling:
Process to determine the amount of dialysis actually given
uses mathematical equation
( refer urea soup pic)

KT/V( Urea)
represnts fractional ura clearance
K= dialyzer clearance
T= time
V= volume of urea distribution

-0.5= uremic, death
-0.7= EEg abnormal
-1.0= short trm 
-1.2-1.4= long term
->1.4= better outcome

Initial hemodynamic prescription concepts; Aim to prescribe a dose of dialysis to effect a desired result

Tubing: < 10 kg- neonatal tubing 
10-20 kg- pediatric tubing
>20 kg adult tubing

SLED & CRRT

Dr. Timothy Buchman

Continuous form of renal replacement therapy that allows for hemodynamic stability

SLED: Slow Low Efficiency Dialysis

Pediatric data for CRRT: optimal use in situation of hemodynamic compromise, Hypermetabolic state, sepsis
45% survival

Pediatric data SLED: 
Heparin Anticoagulation
14 children in 16 sessions. less than 8 hours.
cheaper than CRRT

Advantages of CRRT:
Continuous in nature making decision making of medication, dosage and nutrition delivery easier. 
Hemodynamically stable

Disadvantages, of CRRT:
greater need of utilization of resources
High pharmacy costs

Adv. of SLED
less resource utilization
less expensive
hemodialysis in morning and nocturnal SLED at night

Disadvantages of SLED
may cause hemodynamic compromise
intermittent
risk of over dialysis due to minimal dialysate flow of 6 ltrs per hour

CME Live: Anticoagulation

CME Live: Anticoagulation

Dr. Rupesh Raina

Curofy- India's largest community of verified doctors covered the CME-International Neonatal and Pediatric Nephrology Training Workshop live. This post was first published on the Curofy app. 

Heparin:

Commonly used
Easy to use and monitor
No evidence on dose
Systemic side effect
Contraindicated in bleeding patient

Citrate

Calcium dependent mechanism 
Binds to free calcium and inhibits binding
Has zero effect upon the patient 
Easy to monitor
Less clotted circuits
Less work of machinery

Problems:

Metabolic alkalosis
Electrolyte disorders
Cardiac toxicity

Complications: 
Seen with rising total calcium with dropping patient ionized calcium.
Citrate gap.

CME Live: Session One

Curofy- India's largest community of verified doctors covered the CME-International Neonatal and Pediatric Nephrology Training Workshop live. This post was first published on the Curofy app. 

Non Dialytic Management of AKI: 

Dr. Rupesh Raina

Modified RIFLE criteria doesn't help on bedside

Creatinins is not the only marker neither is it good.
Solute clearance
Risk assessment
Early intervention is critical in golden hour
Normal saline is the best for fluid replacement - gives them proteins, hypercatabolic state
Contrast induced neprotoxicity should be avoided. No contrast MRI

Nutrition in AKI 

Dr. Timothy buchman

Protein energy waste= increased morbidity & mortality

Hypoglycemis:
Altered substrate utilization in acute illness:
Inefficient oxidation, impaired glycogenesis, lipogenesis
Insulin resistance

Protein metablism:
Muscle efflux of amino acid to fuel gluconeogenesis
Liver protein synthesis shifts from anabolic to acute phase proteins. 
Net negetive nitrogen protein balance

Lipid metabolism:
Increased triglyceride
Decreased cholestrol
Impaired lipolysis

Water soluble vitamins:

Vit B1 def. altered energy metabolism
Vit B6 def: altered amino acid and lipid metabolism
Folate deficiency: anemia
Vit c def: potential for losses during CRRT

CME Live: Hyperammonaemia and CRRT in acute liver failure

CME Live: Hyperammonaemia and CRRT in acute liver failure

Dr. Timothy Buchman

Curofy- India's largest community of verified doctors covered the CME-International Neonatal and Pediatric Nephrology Training Workshop live. This post was first published on the Curofy app. 

Indication of RRT in ALF
Hepatic encephalopathy grade 3-4
Renal dysfunction
Metabolic abnormalities
No one indication is an absolute one in for initiation of RRT

RRT in CLD
Supportive therapy for kids who deteriorate
Volume overload, intractable metabolic acidosis, and hyperkalemia
Delay in RRT decreases mortality by 90% 
Serves as a bridge to transplant

Modalities:

CRRT-CVVH, CVVHD CVVHDF- no evidence which was bettter 
TPE- therapeutic plasma exchange 
MARS
SPAD: single pass albumin dialysis

No evidence for RRT in liver patients

Should we undertake CRRT in ALF?

Yes and review 
For neuroprotection, metabolic disarray, bridge for recovery or transplant
CRRT- unstable
TPE- the way to go

Dose: No evidence in pediatrics, High is gaining popularity

Anticoagulation: PGI2 and low dose heparin

CME Live: Hemolytic Uremic Syndrome

CME Live: Hemolytic Uremic Syndrome

Dr Siddhartha Sethi

Curofy- India's largest community of verified doctors covered the CME-International Neonatal and Pediatric Nephrology Training Workshop live. This post was first published on the Curofy app. 

Etiology
Infection: Shiga and verocytotoxin
Steptococcus Pneumoniae disorders: 

a) genetic disorders of complement regulation
b) Acquired disorders of complement regulation

VonWillebrand proteinase:

a) Genetic disorder
b) Acquired
HIV
Malignancy
Lupus

Complement studies should be a part of every HUS evaluation
Diarrhea+ HUS in young, severe, recurrent, family history
Early: plasma infusions, plasma exchange
Recurrence post renal transplant
Immunosuppression 
Eculizumab

Renal transplant in HUS
High rate of recurrence
Factor H & I mutation
Patients ideally not living related to non-Stx-HUS

Eculizumab: most expensive drug trial

CME Live: Pediatric Palliative Care: Chronic kidney disease

CME Live: Pediatric Palliative Care: Chronic kidney disease

Dr Mona Gupta

Curofy- India's largest community of verified doctors covered the CME-International Neonatal and Pediatric Nephrology Training Workshop live. This post was first published on the Curofy app. 

In life threatening conditions Goals would be to:

Enhance quality of life

Minimize suffering

Optimize function

Interdisciplinary roles:

Pediatricians:

Initiate treatment

Decision making and future care

Care co-ordination

Nephrologist: 

- Replacing electrolytes

Psycologist:

-Family

Palliative care works towards 

Family bereavement

Support

Maximize quality of life

Minimize time

Benefits:

Attention to symptoms and quality of life

End of life preparation

Pain and symptom management

Early involvement beneficial to family, child, caregiver. 

CME LIVE: International Neonatal and Pediatric Nephrology Training Workshop

Curofy- India's largest community of verified doctors covered the CME-International Neonatal and Pediatric Nephrology Training Workshop live. This post was first published on the Curofy app. 

https://bnc.it/z53c/KW9zY4k0at

ACUTE KIDNEY INJURY

Most common cause: Post cardiac surgery
62% of neonates undergoing cardiac surgery develop AKI

1 in every 3 child in hospital contracts acute kidney injury

Children on ventilators: 36% of children on ventilators develop AKI
Inotrope score: increased postsurgery Inotrope, increased risks

AKI in non critically ill children:
Risk factors : longer treatment, AG treatment in previous months

How to prevent damage?

Decreased nephrotoxic drugs
Regulate hypotension

Fluid overload calculation 

Increased fluid overload means increased fatality
Fluid accumulation and fatality is independent of the critical condition of the patient, 

Survival rates fall down with increased fluid accumulation

Oxygenation is directly proportional to fluid overload

Renal Angina Index= risk of AKI*signs of injury

RAI predicts the survival and fluid overload. decreased RAI decreased risk of AKI